Title : Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design.

Pub. Date : 2003 Oct

PMID : 12893843






3 Functional Relationships(s)
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1 Extensive in vitro tests of these oximes with acetylcholinesterase inhibited by two different organophosphate agents, echothiophate and diisopropylfluorophosphate, revealed one compound with particularly good reactivation kinetics and affinity for phosphorylated acetylcholinesterase (AChE). Isoflurophate acetylcholinesterase Rattus norvegicus
2 Extensive in vitro tests of these oximes with acetylcholinesterase inhibited by two different organophosphate agents, echothiophate and diisopropylfluorophosphate, revealed one compound with particularly good reactivation kinetics and affinity for phosphorylated acetylcholinesterase (AChE). Isoflurophate acetylcholinesterase Rattus norvegicus
3 Extensive in vitro tests of these oximes with acetylcholinesterase inhibited by two different organophosphate agents, echothiophate and diisopropylfluorophosphate, revealed one compound with particularly good reactivation kinetics and affinity for phosphorylated acetylcholinesterase (AChE). Isoflurophate acetylcholinesterase Rattus norvegicus