Title : NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertension.

Pub. Date : 2003 Sep

PMID : 12885792






2 Functional Relationships(s)
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1 The present study tested the hypotheses that ET-1 stimulates venous NADPH oxidase and superoxide via its ET(A) receptors, resulting in enhanced venoconstriction in DOCA-salt hypertensive rats. Desoxycorticosterone Acetate endothelin 1 Rattus norvegicus
2 Moreover, ET-1 treatment (10(-9) mol/L, 10 minutes) of isolated vena cavas further elevated superoxide levels in DOCA-salt rats only but not sham rats, an effect that was abrogated by the superoxide scavenger tempol. Desoxycorticosterone Acetate endothelin 1 Rattus norvegicus