Pub. Date : 2003 Aug
PMID : 12884300
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ME3738 protects from concanavalin A-induced liver failure via an IL-6-dependent mechanism. | ME3738 | interleukin 6 | Mus musculus |
| 2 | The protective effect of ME3738 prior to Con A injection was associated with a reduction in IL-6 serum levels and NF-kappaB DNA binding in liver nuclear extracts. | ME3738 | interleukin 6 | Mus musculus |
| 3 | Further analysis showed that ME3738 induces IL-6 serum levels and activates STAT3 DNA binding and target gene transcription. | ME3738 | interleukin 6 | Mus musculus |
| 4 | Therefore, we demonstrate that ME3738 triggers IL-6 expression, which activates pathways that are relevant to protect from Con A-induced liver failure. | ME3738 | interleukin 6 | Mus musculus |