Title : Reduced glucocorticoid sensitivity of monocyte interleukin-6 production in male industrial employees who are vitally exhausted.

Pub. Date : 2003 Jul-Aug

PMID : 12883121






3 Functional Relationships(s)
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1 Inhibition of IL-6 release was determined by coincubation with increasing concentrations of dexamethasone. Dexamethasone interleukin 6 Homo sapiens
2 Monocyte glucocorticoid sensitivity was defined as the dexamethasone concentration inhibiting IL-6 release by 50%. Dexamethasone interleukin 6 Homo sapiens
3 However, in highly exhausted participants, dexamethasone was less able to inhibit IL-6 release (p=.010), and the glucocorticoid sensitivity was lower (p=.003) than in nonexhausted subjects. Dexamethasone interleukin 6 Homo sapiens