Title : Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization.

Pub. Date : 2003 Aug

PMID : 12874449






4 Functional Relationships(s)
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1 Stimulation of PKC with sn-1,2-dioctanoylglycerol resulted in strong inhibition of p-aminohippurate transport mediated by the cloned human organic anion transporter 1 (hOAT1) expressed in Xenopus oocytes and HEK293 cells, as well as hOAT1 internalization in both expression systems. p-Aminohippuric Acid solute carrier family 22 member 6 Homo sapiens
2 Stimulation of PKC with sn-1,2-dioctanoylglycerol resulted in strong inhibition of p-aminohippurate transport mediated by the cloned human organic anion transporter 1 (hOAT1) expressed in Xenopus oocytes and HEK293 cells, as well as hOAT1 internalization in both expression systems. p-Aminohippuric Acid solute carrier family 22 member 6 Homo sapiens
3 Stimulation of PKC with sn-1,2-dioctanoylglycerol resulted in strong inhibition of p-aminohippurate transport mediated by the cloned human organic anion transporter 1 (hOAT1) expressed in Xenopus oocytes and HEK293 cells, as well as hOAT1 internalization in both expression systems. p-Aminohippuric Acid solute carrier family 22 member 6 Homo sapiens
4 It was independent of the conserved canonical PKC consensus sites in hOAT1, however, and was unaffected by agents that destabilize actin filaments or microtubules, which altered baseline hOAT1-mediated p-aminohippurate uptake activity in oocytes. p-Aminohippuric Acid solute carrier family 22 member 6 Homo sapiens