Title : HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection.

Pub. Date : 2003 Jul 19

PMID : 12871602






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Concurrent treatment with mevalonolactone prevented the induction of apoptosis and suppressed both IL-1beta and IL-1Ra release in response to LPS, suggesting a rate-limiting role for HMG-CoA reductase in monocyte differentiation. mevalonolactone interleukin 1 receptor antagonist Homo sapiens