Title : Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquinolines.

Pub. Date : 2002 Nov-Dec

PMID : 12866710






2 Functional Relationships(s)
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1 1-Methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) is an exogenous neurotoxin producing parkinsonism in humans, monkeys and various animals as the result of MAOB-catalyzed conversion of it to the 1-methyl-4-phenyl-pyridinium ion (MPP+), which selectively kills the nigrostriatal dopaminergic neurons. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Homo sapiens
2 1-Methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) is an exogenous neurotoxin producing parkinsonism in humans, monkeys and various animals as the result of MAOB-catalyzed conversion of it to the 1-methyl-4-phenyl-pyridinium ion (MPP+), which selectively kills the nigrostriatal dopaminergic neurons. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Homo sapiens