Title : Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses.

Pub. Date : 2003 Aug

PMID : 12865660






2 Functional Relationships(s)
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1 Increased IL-8 in the culture medium of human umbilical vein (HUVEC), lung microvascular, and iliac artery endothelial cells was observed 24 h after the addition of 10 to 50 microM CuCl2 (cupric ions). cupric chloride C-X-C motif chemokine ligand 8 Homo sapiens
2 HUVEC IL-8 mRNA increased 3 h after CuCl2 stimulation and remained elevated after 24 h, implying sustained transcriptional activation. cupric chloride C-X-C motif chemokine ligand 8 Homo sapiens