Title : Sex differences in estrogen-dependent transcription of gonadotropin-releasing hormone (GnRH) gene revealed in GnRH transgenic mice.

Pub. Date : 2003 Aug

PMID : 12865313






3 Functional Relationships(s)
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1 The mechanisms through which gonadal steroids exert feedback actions on the activity of the GnRH neurons are not understood. Steroids gonadotropin releasing hormone 1 Mus musculus
2 Using a series of GnRH-LacZ transgenic mice we have examined the manner in which gonadal steroids suppress GnRH mRNA expression in male and female mice. Steroids gonadotropin releasing hormone 1 Mus musculus
3 The same mechanism does not exist in females, indicating that gonadal steroids suppress GnRH mRNA levels in a sexually dimorphic manner. Steroids gonadotropin releasing hormone 1 Mus musculus