Pub. Date : 2003 Aug
PMID : 12851688
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The differential sensitivity of cells to edelfosine"s cytostatic and cytotoxic effects has been attributed to edelfosine-induced changes in the activities of many enzymes, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), p38 kinase, and poly(ADP-ribose) polymerase (PARP). | edelfosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | The differential sensitivity of cells to edelfosine"s cytostatic and cytotoxic effects has been attributed to edelfosine-induced changes in the activities of many enzymes, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), p38 kinase, and poly(ADP-ribose) polymerase (PARP). | edelfosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | The differential sensitivity of cells to edelfosine"s cytostatic and cytotoxic effects has been attributed to edelfosine-induced changes in the activities of many enzymes, including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinases (ERK), p38 kinase, and poly(ADP-ribose) polymerase (PARP). | edelfosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Three out of the four edelfosine-sensitive NSCLC cell lines (NCI-H157, NCI-H520, NCI-H522) exhibit G2/M arrest, significant apoptosis and some degree of JNK activation in response to drug treatment. | edelfosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | These results demonstrate that edelfosine-induced changes in JNK, ERK, p38, or PARP are not good predictors of cell susceptibility to edelfosine-induced cytotoxicity. | edelfosine | mitogen-activated protein kinase 8 | Homo sapiens |