Title : Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites.

Pub. Date : 2003 Oct 3

PMID : 12851386






2 Functional Relationships(s)
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1 To accelerate the process of identifying cyclic compounds with high affinity for the AChE P-site, we introduced a cysteine residue near the rim of the P-site by site-specific mutagenesis to generate recombinant human H287C AChE. Cysteine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 To accelerate the process of identifying cyclic compounds with high affinity for the AChE P-site, we introduced a cysteine residue near the rim of the P-site by site-specific mutagenesis to generate recombinant human H287C AChE. Cysteine acetylcholinesterase (Cartwright blood group) Homo sapiens