Pub. Date : 2003 May
PMID : 12846439
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NCX-4016 consists of the parent molecule (aspirin) linked to a "spacer" via an ester linkage, which is in turn connected to a nitric oxide-releasing moiety. | Aspirin | T cell leukemia homeobox 2 | Homo sapiens |
| 2 | Both aspirin and nitric oxide moieties of NCX-4016 contribute to its effectiveness, the latter occurring via both cyclic guanosyl monophosphate-dependent and -independent mechanisms. | Aspirin | T cell leukemia homeobox 2 | Homo sapiens |
| 3 | In vitro studies have shown that NCX-4016 inhibits platelet aggregation induced by aspirin-sensitive (arachidonic acid) and aspirin-insensitive (thrombin) agonist. | Aspirin | T cell leukemia homeobox 2 | Homo sapiens |
| 4 | In vitro studies have shown that NCX-4016 inhibits platelet aggregation induced by aspirin-sensitive (arachidonic acid) and aspirin-insensitive (thrombin) agonist. | Aspirin | T cell leukemia homeobox 2 | Homo sapiens |
| 5 | Indeed, a 7-day course of NCX-4016 results in 90% reduction of gastric damage caused by equimolar doses of aspirin. | Aspirin | T cell leukemia homeobox 2 | Homo sapiens |