Title : Effect of ligands of nuclear hormone receptors on sodium/iodide symporter expression and activity in breast cancer cells.

Pub. Date : 2003 Jun

PMID : 12846418






1 Functional Relationships(s)
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1 9-cis retinoic acid (9-cis RA), a ligand for both retinoic acid receptor (RAR)/retinoic X receptor (RXR) heterodimers as well as RXR/RXR homodimers, markedly induced NIS mRNA expression in MCF-7 breast cancer cells in a dose- and time-dependent fashion, with maximal levels occurring at 12 h. All-trans retinoic acid, ATRA, a RAR specific ligand had a similar potency. Tretinoin retinoid X receptor alpha Homo sapiens