Pub. Date : 2003 Jul
PMID : 12843192
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of mitogen-activated protein kinase in insulin and insulin-like growth factor I (IGF-I) signaling cascades for progesterone and IGF-binding protein-1 production in human granulosa cells. | Progesterone | insulin like growth factor 1 | Homo sapiens |
| 2 | The role of mitogen-activated protein kinase in insulin and insulin-like growth factor I (IGF-I) signaling cascades for progesterone and IGF-binding protein-1 production in human granulosa cells. | Progesterone | insulin like growth factor 1 | Homo sapiens |
| 3 | We now examined whether activation of MAPK is necessary to mediate insulin-induced or IGF-I-induced stimulation of progesterone or inhibition of IGFBP-1 production in human granulosa cells. | Progesterone | insulin like growth factor 1 | Homo sapiens |
| 4 | Progesterone production in granulosa cells was stimulated by IGF-I to 130% of the control value (P < 0.001), whereas IGFBP-1 production was inhibited to 44% of the control value (P < 0.001). | Progesterone | insulin like growth factor 1 | Homo sapiens |
| 5 | In the presence of 1 micro M PD98059, IGF-I-induced stimulation of progesterone production was inhibited by 96% (P < 0.001). | Progesterone | insulin like growth factor 1 | Homo sapiens |