Title : ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics.

Pub. Date : 2003 Jul 15

PMID : 12837691






1 Functional Relationships(s)
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1 The carboxy-terminus of ALS2 protein carrying a VPS9 domain mediates not only the activation of Rab5 via a guanine-nucleotide exchanging reaction but also the endosomal localization of the ALS2 protein, while the amino-terminal half containing RLD acts suppressive in its membranous localization. Guanine Nucleotides RAB5A, member RAS oncogene family Homo sapiens