Title : Cot/Tpl2 is essential for RANKL induction by lipid A in osteoblasts.

Pub. Date : 2003 Jul

PMID : 12821717






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we show that RANKL mRNA induction and ERK activation, when treated with synthetic lipid A (an active center of LPS), were markedly reduced in mouse osteoblasts lacking Cot/Tpl2, which was recently recognized as an essential kinase for the induction of TNF-alpha by LPS in macrophages. Lipid A mitogen-activated protein kinase 1 Mus musculus