Pub. Date : 2003 Jul
PMID : 12814972
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Recombinant CYP3A4 and CYP3A5 (rCYP3A4 and rCYP3A5) both produced 1-OH and 4-OH metabolites from midazolam and triazolam, 6 beta-hydroxytestosterone from testosterone, and oxidized nifedipine from nifedipine. | Triazolam | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
2 | Thus, CYP3A4 and CYP3A5 both contribute to midazolam, triazolam, testosterone, and nifedipine biotransformation in HLMs, with CYP3A5 being metabolically less active than CYP3A4 in general. | Triazolam | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |