Title : Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile.

Pub. Date : 2003 Jul

PMID : 12814968






2 Functional Relationships(s)
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1 In wild-type mice, PCN treatment significantly increased UGT activities toward bilirubin, 1-naphthol, chloramphenicol, thyroxine, and triiodothyronine. 1-naphthol solute carrier family 35 (UDP-galactose transporter), member A2 Mus musculus
2 On control diet, the UGT activities toward the above substrates (except for 1-naphthol) in the PXR-null mice were significantly higher than those of wild-type mice. 1-naphthol solute carrier family 35 (UDP-galactose transporter), member A2 Mus musculus