Pub. Date : 2003 Aug 29
PMID : 12810713
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of polyglutamine-expanded huntingtin induced elevation of phosphorylated or activated Src and increased targeting of PSD-95 (post-synaptic density 95) and activated Src to cell surface membrane. | polyglutamine | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Expression of polyglutamine-expanded huntingtin induced elevation of phosphorylated or activated Src and increased targeting of PSD-95 (post-synaptic density 95) and activated Src to cell surface membrane. | polyglutamine | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Taken together, our studies show that polyglutamine-expanded huntingtin increases tyrosine phosphorylation of NMDA receptors via PSD-95 and Src, and increased tyrosine phosphorylation may contribute to the sensitization of the receptors mediated by polyglutamine-expanded huntingtin. | polyglutamine | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |