Title : pVHL-independent ubiquitination of HIF1alpha and its stabilization by cobalt ion.

Pub. Date : 2003 Jul 4

PMID : 12810083






2 Functional Relationships(s)
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1 We also demonstrated that Co(2+) binds to both PAS domains in the N-terminal region of HIF1alpha. Protactinium hypoxia inducible factor 1 subunit alpha Homo sapiens
2 These observations imply that the stability of HIF1alpha is regulated by an additional pathway through the cobalt binding of PAS domains. Protactinium hypoxia inducible factor 1 subunit alpha Homo sapiens