Pub. Date : 2003 Jul
PMID : 12807762
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of cells with TPA results in the activation and subsequent depletion of the TPA-responsive protein kinase C (PKC) isoforms. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 2 | Treatment of cells with TPA results in the activation and subsequent depletion of the TPA-responsive protein kinase C (PKC) isoforms. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 3 | Prolonged TPA treatment induced down-regulation of PKCalpha, delta and epsilon and a reduction in the total PKC activity, which was associated with recovery of GJIC. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 4 | Prolonged TPA treatment induced down-regulation of PKCalpha, delta and epsilon and a reduction in the total PKC activity, which was associated with recovery of GJIC. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 5 | Co-treatment of IAR20 cells with TPA and the proteasomal inhibitor MG132 suppressed down-regulation of PKCalpha, delta and epsilon and caused prolonged PKC activity. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 6 | Co-treatment of IAR20 cells with TPA and the proteasomal inhibitor MG132 suppressed down-regulation of PKCalpha, delta and epsilon and caused prolonged PKC activity. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 7 | The general PKC inhibitor GF109203X reversed the effect of MG132, indicating that the prolonged TPA-induced inhibition of GJIC caused by MG132 was due to the prolonged PKC activity. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 8 | The general PKC inhibitor GF109203X reversed the effect of MG132, indicating that the prolonged TPA-induced inhibition of GJIC caused by MG132 was due to the prolonged PKC activity. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 9 | These results indicate that proteasomal degradation of PKC is one mechanism by which the recovery of GJIC after TPA treatment is regulated. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |