Title : Oxidative DNA damage and repair in a cell lineage model of human proliferative breast disease (PBD).

Pub. Date : 2003 Sep

PMID : 12805649






1 Functional Relationships(s)
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1 These results demonstrate that, in this cell lineage, sensitivity to oxidative DNA damage by H2O2 decreases with tumorigenicity (i.e., MCF-10A vs. MCF-10ATG3B), and show that DNA repair, altered Ras, and p53 expression, or compensatory mechanisms involving elevated antioxidant enzymes are involved in mediating these effects. Hydrogen Peroxide tumor protein p53 Homo sapiens