Title : Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells.

Pub. Date : 2003 Jun

PMID : 12802498






2 Functional Relationships(s)
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1 AIMS/HYPOTHESIS: Increased flux through the hexosamine biosynthetic pathway with glutamine:fructose-6-phosphate aminotransferase (GFAT) as a rate-limiting enzyme has been linked to the enhanced bioactivity of the prosclerotic cytokine TGF-beta1, a key mediator in the development of diabetic nephropathy and possibly other diabetic angiopathies. Hexosamines glutamine--fructose-6-phosphate transaminase 1 Homo sapiens
2 CONCLUSION/INTERPRETATION: The data indicate that the hexosamine pathway-mediated induction of TGF-beta1 synthesis in mesangial cells is dependent on GFAT enzyme activity. Hexosamines glutamine--fructose-6-phosphate transaminase 1 Homo sapiens