Title : Increased expression of cyclin E is associated with an increased resistance to doxorubicin in rat fibroblasts.

Pub. Date : 2003 Jun 16

PMID : 12799643






1 Functional Relationships(s)
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1 These results suggest that cyclin E overexpression might reduce tumour cells sensitivity to doxorubicin by affecting the expression of MnSOD and that determination of cyclin E expression levels might help to select patients to be treated with an anthracycline-based antineoplastic therapy. Doxorubicin superoxide dismutase 2 Homo sapiens