Title : Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.

Pub. Date : 1992 Nov 15

PMID : 1279700






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Using an FK506 affinity column to identify mammalian immunosuppressant-binding proteins, we identified an immunophilin with an apparent M(r) approximately 55,000, which we have named FKBP52. Tacrolimus FKBP prolyl isomerase 4 Homo sapiens
2 Recombinant hFKBP52 has peptidyl-prolyl cis-trans isomerase activity that is inhibited by FK506 and rapamycin and an FKBP12-like consensus sequence that probably defines the immunosuppressant-binding site. Tacrolimus FKBP prolyl isomerase 4 Homo sapiens