Pub. Date : 2003 Jun 10
PMID : 12796536
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PIP2 binding residues of Kir2.1 are common targets of mutations causing Andersen syndrome. | Phosphatidylinositol 4,5-Diphosphate | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |
| 2 | CONCLUSIONS: The novel mutations corresponding to residues involved in Kir2.1 channel-PIP2 interactions presented here as well as the overall frequency of mutations occurring in these residues indicate that defects in PIP2 binding constitute a major pathogenic mechanism of ATS. | Phosphatidylinositol 4,5-Diphosphate | potassium inwardly rectifying channel subfamily J member 2 | Homo sapiens |