Title : Kinetics of iodide uptake and efflux in various human thyroid cancer cells by expressing sodium iodide symporter gene via a recombinant adenovirus.

Pub. Date : 2003 Jul-Aug

PMID : 12792733






5 Functional Relationships(s)
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1 These hNIS-transduced cells actively transported iodide into the cytoplasm at the level of 11635.3, 61571.6, and 19367.5 pmoles/10(6) cells in ARO, FRO, and NPA, respectively. Iodides solute carrier family 5 member 5 Homo sapiens
2 The present study indicates that functional hNIS can be efficiently expressed and is responsible for active transport of iodide in hNIS-negative human thyroid cancer cells by a recombinant adenovirus. Iodides solute carrier family 5 member 5 Homo sapiens
3 The present study indicates that functional hNIS can be efficiently expressed and is responsible for active transport of iodide in hNIS-negative human thyroid cancer cells by a recombinant adenovirus. Iodides solute carrier family 5 member 5 Homo sapiens
4 Therefore, these kinetic characteristics of iodide uptake and efflux may limit the therapeutic potential of hNIS/radioiodide-based treatment following exogenous hNIS expression in human thyroid cancer. Iodides solute carrier family 5 member 5 Homo sapiens
5 Therefore, these kinetic characteristics of iodide uptake and efflux may limit the therapeutic potential of hNIS/radioiodide-based treatment following exogenous hNIS expression in human thyroid cancer. Iodides solute carrier family 5 member 5 Homo sapiens