Title : Molecular basis for atovaquone binding to the cytochrome bc1 complex.

Pub. Date : 2003 Aug 15

PMID : 12791689






1 Functional Relationships(s)
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1 A computed energy-minimized structure for atovaquone liganded to the yeast bc1 complex suggests that a phenylalanine at position 275 of cytochrome b in the bovine bc1 complex, as opposed to leucine at the equivalent position in the yeast enzyme, is responsible for the decreased sensitivity of the bovine bc1 complex (Ki = 80 nm) to atovaquone. Phenylalanine cytochrome b Saccharomyces cerevisiae S288C