Title : Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).

Pub. Date : 2003 Jun

PMID : 12790799






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). Phorbol Esters protein kinase C, gamma Rattus norvegicus
2 To further investigate whether conventional or novel PKC isoforms adversely affect beta-cell proliferation, the effect of phorbol ester (phorbol 12-myristate 13-acetate; PMA)-mediated activation of these PKC isoforms on glucose/IGF-I-induced INS-1 cell mitogenesis, and insulin receptor substrate (IRS)-mediated signal transduction was investigated. Phorbol Esters protein kinase C, gamma Rattus norvegicus