Title : Secretion of matrix metalloproteinase-9 by the proinflammatory cytokine, IL-1beta: a role for the dual signalling pathways, Akt and Erk.

Pub. Date : 2003 Jun

PMID : 12786942






1 Functional Relationships(s)
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1 Treatment of cells with either LY294002, a PI3K inhibitor, or expression of a dominant negative form of Akt drastically suppressed the IL-1beta-dependent secretion of MMP-9. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one interleukin 1 beta Mus musculus