Title : [Effect of levcromakalim and cromakalim on ATP-sensitive K+ channel of pulmonary arterial smooth muscle cells in pulmonary hypertensive rats].

Pub. Date : 2003 Feb

PMID : 12783661






3 Functional Relationships(s)
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1 A dose-dependent decreasing effect on mPAP was elicited by levcromakalim and cromakalim in the hypoxic rats. Cromakalim phospholipid phosphatase 1 Mus musculus
2 CONCLUSION: Although K(ATP) activity is probably not directly involved in the development of chronic hypoxic pulmonary hypertension in rats, both levcromakalim and cromakalim decrease the increased mPAP induced by chronic hypoxia by activating K(ATP) of SMCs from pulmonary arteries, therefore diminishing the inhibitory effect of hypoxia on other K(+) channels. Cromakalim phospholipid phosphatase 1 Mus musculus
3 CONCLUSION: Although K(ATP) activity is probably not directly involved in the development of chronic hypoxic pulmonary hypertension in rats, both levcromakalim and cromakalim decrease the increased mPAP induced by chronic hypoxia by activating K(ATP) of SMCs from pulmonary arteries, therefore diminishing the inhibitory effect of hypoxia on other K(+) channels. Cromakalim phospholipid phosphatase 1 Mus musculus