Title : Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid.

Pub. Date : 2003 Jun 1

PMID : 12781337






1 Functional Relationships(s)
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1 The results indicated that there was approximately one order of magnitude of interindividual variation in the expression of CYP1A2 and UGT2B7, activity of the enzymes toward DMXAA, and inhibition potency (IC(50)) by diclofenac, cyproheptadine, and alpha-naphthoflavone. Diclofenac cytochrome P450 family 1 subfamily A member 2 Homo sapiens