Title : Human carboxylesterase 1: from drug metabolism to drug discovery.

Pub. Date : 2003 Jun

PMID : 12773168






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 hCE1 catalyses the hydrolysis of heroin and cocaine, and the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene. Cocaine carboxylesterase 1 Homo sapiens
2 hCE1 catalyses the hydrolysis of heroin and cocaine, and the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene. Cocaine carboxylesterase 1 Homo sapiens
3 We have determined the crystal structures of hCE1 in complex with either the cocaine analogue homatropine or the heroin analogue naloxone. Cocaine carboxylesterase 1 Homo sapiens