Title : Regulation by prostaglandin E2 and histamine of angiogenesis in inflammatory granulation tissue.

Pub. Date : 2003 May

PMID : 12772586






4 Functional Relationships(s)
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1 Histamine also induced VEGF production in the granulation tissue in vitro. Histamine vascular endothelial growth factor A Mus musculus
2 The H2 receptor antagonist cimetidine, the cAMP antagonist Rp-cAMP and the protein kinase A inhibitor H-89 suppressed the histamine-induced VEGF production in the granulation tissue. Histamine vascular endothelial growth factor A Mus musculus
3 These findings suggest that PGE2 and histamine augment angiogenesis in the inflammatory granulation tissue by inducing VEGF production, and histamine induces VEGF production possibly through the H2 receptor--cAMP--protein kinase A pathway. Histamine vascular endothelial growth factor A Mus musculus
4 These findings suggest that PGE2 and histamine augment angiogenesis in the inflammatory granulation tissue by inducing VEGF production, and histamine induces VEGF production possibly through the H2 receptor--cAMP--protein kinase A pathway. Histamine vascular endothelial growth factor A Mus musculus