Pub. Date : 2003 May 22
PMID : 12761496
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells. | Paclitaxel | H3 histone pseudogene 16 | Homo sapiens |
| 2 | CKI p21 is a regulator of cellular responses to microtubule damage induced by drugs such as paclitaxel (PTX). | Paclitaxel | H3 histone pseudogene 16 | Homo sapiens |
| 3 | CKI p21 is a regulator of cellular responses to microtubule damage induced by drugs such as paclitaxel (PTX). | Paclitaxel | H3 histone pseudogene 16 | Homo sapiens |
| 4 | We demonstrated here that low doses of PTX that are unable to activate the spindle assembly checkpoint, upregulate p21 by a p53-dependent pathway and induce its translocation to the cytoplasm. | Paclitaxel | H3 histone pseudogene 16 | Homo sapiens |
| 5 | Furthermore, the cytoplasmic p21 accumulation observed in PTX-treated cells was inhibited by LY 294002, a specific PI-3 kinase inhibitor or by the expression of a dominant-negative AKT mutant. | Paclitaxel | H3 histone pseudogene 16 | Homo sapiens |
| 6 | However, the kinase activity of AKT was unchanged in PTX-treated cells, suggesting that low doses of PTX could regulate p21 phosphorylation via inhibition of its dephosphorylation. | Paclitaxel | H3 histone pseudogene 16 | Homo sapiens |