Title : Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells.

Pub. Date : 2003 May 22

PMID : 12761496






6 Functional Relationships(s)
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1 Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells. Paclitaxel H3 histone pseudogene 16 Homo sapiens
2 CKI p21 is a regulator of cellular responses to microtubule damage induced by drugs such as paclitaxel (PTX). Paclitaxel H3 histone pseudogene 16 Homo sapiens
3 CKI p21 is a regulator of cellular responses to microtubule damage induced by drugs such as paclitaxel (PTX). Paclitaxel H3 histone pseudogene 16 Homo sapiens
4 We demonstrated here that low doses of PTX that are unable to activate the spindle assembly checkpoint, upregulate p21 by a p53-dependent pathway and induce its translocation to the cytoplasm. Paclitaxel H3 histone pseudogene 16 Homo sapiens
5 Furthermore, the cytoplasmic p21 accumulation observed in PTX-treated cells was inhibited by LY 294002, a specific PI-3 kinase inhibitor or by the expression of a dominant-negative AKT mutant. Paclitaxel H3 histone pseudogene 16 Homo sapiens
6 However, the kinase activity of AKT was unchanged in PTX-treated cells, suggesting that low doses of PTX could regulate p21 phosphorylation via inhibition of its dephosphorylation. Paclitaxel H3 histone pseudogene 16 Homo sapiens