Title : Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro.

Pub. Date : 2003 Jun

PMID : 12761334






1 Functional Relationships(s)
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Protein Name
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1 TPZ requires metabolic activation to give a cytotoxic free radical species, and this hypoxia-mediated process is carried out by a variety of cellular reductases, including NADPH cytochrome c (P450) reductase (P540R). Free Radicals cytochrome c, somatic Homo sapiens