Pub. Date : 2003 Jun 1
PMID : 12759456
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In response to ATP binding, the P2X7R facilitates cation channel activation, nonspecific pore formation, rapid changes in plasma membrane morphology, and secretion of IL-1 beta from LPS-primed macrophages. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 2 | Blebbing was initiated at ATP concentrations > or = 3 mM, but optimal IL-1 beta release occurred at 1 mM ATP. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 3 | P2X7R-dependent blebbing was abrogated in the presence of Rho-effector kinase inhibitors Fasudil and Y-27632, but ATP-induced IL-1 beta release was unaffected. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |