Pub. Date : 2003 May
PMID : 12752443
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Co-operation of domain-binding and calcium-binding sites in the activation of gelsolin. | Calcium | gelsolin | Homo sapiens |
| 2 | Gelsolin is an abundant calcium dependent actin filament severing and capping protein. | Calcium | gelsolin | Homo sapiens |
| 3 | It is generally held that a "helical-latch" at the C-terminus of gelsolin"s domain 6 (G6), binds domain 2 (G2) to keep gelsolin in the calcium-free compact state, and that the crutial calcium binding site(s) reside in the C-terminal half of gelsolin perhaps involving the C-terminal helix itself has to be bound to release this latch. | Calcium | gelsolin | Homo sapiens |
| 4 | It is generally held that a "helical-latch" at the C-terminus of gelsolin"s domain 6 (G6), binds domain 2 (G2) to keep gelsolin in the calcium-free compact state, and that the crutial calcium binding site(s) reside in the C-terminal half of gelsolin perhaps involving the C-terminal helix itself has to be bound to release this latch. | Calcium | gelsolin | Homo sapiens |
| 5 | It is known that the activation of gelsolin involves multiple calcium binding events (around 6) the first of which (in G6) may release the latch. | Calcium | gelsolin | Homo sapiens |
| 6 | Additional calcium binding in other domains then result in the complete opening and activation of the gelsolin molecule. | Calcium | gelsolin | Homo sapiens |