Title : Molecular modelling of CYP2B6 based on homology with the CYP2C5 crystal structure: analysis of enzyme-substrate interactions.

Pub. Date : 2002

PMID : 12751910






1 Functional Relationships(s)
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1 Quantitative Structure-Activity Relationships (QSARs) for substrates binding to CYP2B6 indicate a key role for hydrogen bonding, and lipophilic character, as determined by the log P parameter (where P is the octanol/water partition coefficient), is also of importance for explaining the variation in experimental binding affinity for CYP2B6 substrates. Hydrogen cytochrome P450 family 2 subfamily B member 6 Homo sapiens