Title : Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats.

Pub. Date : 2002

PMID : 12751907






2 Functional Relationships(s)
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1 Intraperitoneal administration of cyclophosphamide was found to decrease the activity of liver antioxidative enzymes, i.e. superoxide dismutase, glutathione peroxidase and glutathione reductase, and to increase catalase activity. Cyclophosphamide glutathione-disulfide reductase Rattus norvegicus
2 Co-administration of cyclophosphamide and amifostine nearly prevented changes in activities of superoxide dismutase, glutathione reductase and catalase, as well as to a high degree of glutathione peroxidase. Cyclophosphamide glutathione-disulfide reductase Rattus norvegicus