Pub. Date : 2003 May 23
PMID : 12742020
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gelsolin domains 4-6 in active, actin-free conformation identifies sites of regulatory calcium ions. | Calcium | gelsolin | Homo sapiens |
| 2 | Structural analysis of gelsolin domains 4-6 demonstrates that the two highest-affinity calcium ions that activate the molecule are in domains 5 and 6, one in each. | Calcium | gelsolin | Homo sapiens |
| 3 | Since the disposition of the three domains is similar in different crystal environments, either free or in complex with actin, the conformation in calcium is intrinsic to active gelsolin itself. | Calcium | gelsolin | Homo sapiens |
| 4 | The last 13 residues of domain 6 have been proposed to be a calcium-activated latch that, in the inhibited form only, links two halves of gelsolin. | Calcium | gelsolin | Homo sapiens |
| 5 | A structural alignment of domain sequences provides a rationale to understand why the two calcium sites found here have the highest affinity amongst the five different candidate sites found in other gelsolin structures. | Calcium | gelsolin | Homo sapiens |