Title : Pericellular plasmin induces smooth muscle cell anoikis.

Pub. Date : 2003 Jul

PMID : 12738809






1 Functional Relationships(s)
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1 The generation of cell-bound plasmin mediated by tissue-type plasminogen activator (t-PA), constitutively expressed by VSMCs, requires binding of plasminogen to the cell surface and is inhibited by epsilon-aminocaproic acid (IC50=0.9+/-0.2 mM), a competitor of plasminogen binding to membrane glycoproteins. Aminocaproic Acid plasminogen Homo sapiens