Title : Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor.

Pub. Date : 2003 May 15

PMID : 12734372






2 Functional Relationships(s)
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1 We observed a decreased accumulation of phosphatidylinositol-3,4,5-trisphosphate in response to fMet-Leu-Phe in LFM-A13-pretreated cells even though the inhibitor had no direct effect on the lipid kinase activity of the p110 gamma or p85/p110 phosphatidylinositol 3-kinases or on the activation of p110 gamma by fMet-Leu-Phe. N-Formylmethionine Leucyl-Phenylalanine phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Homo sapiens
2 We observed a decreased accumulation of phosphatidylinositol-3,4,5-trisphosphate in response to fMet-Leu-Phe in LFM-A13-pretreated cells even though the inhibitor had no direct effect on the lipid kinase activity of the p110 gamma or p85/p110 phosphatidylinositol 3-kinases or on the activation of p110 gamma by fMet-Leu-Phe. N-Formylmethionine Leucyl-Phenylalanine phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Homo sapiens