Title : Alterations in cellular IRP-dependent iron regulation by in vitro manganese exposure in undifferentiated PC12 cells.

Pub. Date : 2003 May 23

PMID : 12729948






6 Functional Relationships(s)
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1 Alterations in cellular IRP-dependent iron regulation by in vitro manganese exposure in undifferentiated PC12 cells. Manganese caspase 3 Rattus norvegicus
2 This latter effect led to a decrease in IRP binding activity at the lower (10 and 50 microM) manganese exposures. Manganese caspase 3 Rattus norvegicus
3 In contrast, 200 microM manganese exposure increased IRP binding, in spite of the significant increase in labile iron. Manganese caspase 3 Rattus norvegicus
4 These data indicate that at lower exposures, manganese directly interfered with IRP-dependent translational events, producing an increase in labile iron, which in turn signaled a decrease in IRP binding at 24 h. At higher exposures, the intracellular burden of manganese resulted in overt cytotoxicity and appeared to compromise the normal compensatory response to increased labile iron, producing increased IRP binding. Manganese caspase 3 Rattus norvegicus
5 These data indicate that at lower exposures, manganese directly interfered with IRP-dependent translational events, producing an increase in labile iron, which in turn signaled a decrease in IRP binding at 24 h. At higher exposures, the intracellular burden of manganese resulted in overt cytotoxicity and appeared to compromise the normal compensatory response to increased labile iron, producing increased IRP binding. Manganese caspase 3 Rattus norvegicus
6 These data indicate that at lower exposures, manganese directly interfered with IRP-dependent translational events, producing an increase in labile iron, which in turn signaled a decrease in IRP binding at 24 h. At higher exposures, the intracellular burden of manganese resulted in overt cytotoxicity and appeared to compromise the normal compensatory response to increased labile iron, producing increased IRP binding. Manganese caspase 3 Rattus norvegicus