Title : Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1.

Pub. Date : 2003 May

PMID : 12727988






1 Functional Relationships(s)
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1 Moreover, the potent MAPK inhibitors, PD98059 and UO126, augment progesterone production in these cell cultures concomitantly with specific elevation of intracellular steroidogenic acute regulatory protein (StAR). Progesterone mitogen-activated protein kinase 3 Homo sapiens