Title : Chk2 activates E2F-1 in response to DNA damage.

Pub. Date : 2003 May

PMID : 12717439






3 Functional Relationships(s)
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1 We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. Etoposide checkpoint kinase 2 Homo sapiens
2 We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. Etoposide checkpoint kinase 2 Homo sapiens
3 Moreover, E2F-1 is resistant to induction by etoposide in tumour cells expressing mutant chk2. Etoposide checkpoint kinase 2 Homo sapiens