Title : Intensive replacement of basal insulin in patients with type 1 diabetes given rapid-acting insulin analog at mealtime: a 3-month comparison between administration of NPH insulin four times daily and glargine insulin at dinner or bedtime.

Pub. Date : 2003 May

PMID : 12716810






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Total daily insulin doses were similar with the three treatments, but with glargine there was an increase in basal and a decrease in mealtime insulin requirements (P < 0.05). Insulin Glargine insulin Homo sapiens
2 Total daily insulin doses were similar with the three treatments, but with glargine there was an increase in basal and a decrease in mealtime insulin requirements (P < 0.05). Insulin Glargine insulin Homo sapiens
3 In-hospital profiles confirmed outpatient blood glucose data and indicated more steady plasma insulin concentrations at night and before meals with glargine versus NPH (P < 0.05). Insulin Glargine insulin Homo sapiens
4 CONCLUSIONS: Regimens of basal insulin with either NPH four times/day or glargine once/day in type 1 diabetic patients both result in good glycemic control. Insulin Glargine insulin Homo sapiens
5 In contrast to NPH, which should be given at bedtime, insulin glargine can be administered at dinnertime without deteriorating blood glucose control. Insulin Glargine insulin Homo sapiens