Title : c-Fos-driven transcriptional activation of transforming growth factor beta-1: inhibition of high glucose-induced promoter activity by thiazolidinediones.

Pub. Date : 2003 May 2

PMID : 12711314






2 Functional Relationships(s)
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1 The findings suggest a molecular mechanism by which TZD-treatment reduces specifically high glucose-induced, c-Fos-mediated gene activation, since phorbol ester-induced c-Fos mRNA and protein expression and subsequent elevation of TGF-beta1 mRNA expression were not prevented by TZDs. Phorbol Esters Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 The findings suggest a molecular mechanism by which TZD-treatment reduces specifically high glucose-induced, c-Fos-mediated gene activation, since phorbol ester-induced c-Fos mRNA and protein expression and subsequent elevation of TGF-beta1 mRNA expression were not prevented by TZDs. Phorbol Esters Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens