Title : c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells.

Pub. Date : 2003 Jul 11

PMID : 12707267






2 Functional Relationships(s)
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1 We showed that JNK was activated by TRAIL and by etoposide and that the activation was enhanced by the combination of the two treatments. Etoposide mitogen-activated protein kinase 8 Homo sapiens
2 In cells treated with TRAIL plus etoposide, JNK inhibition increased cell survival and decreased apoptosis significantly. Etoposide mitogen-activated protein kinase 8 Homo sapiens