Pub. Date : 2003 May 15
PMID : 12704788
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interferon-gamma induces reactive oxygen species and endoplasmic reticulum stress at the hepatic apoptosis. | Reactive Oxygen Species | interferon gamma | Homo sapiens |
| 2 | In this study, we found that IFN-gamma induced generation of reactive oxygen species (ROS) in primary hepatocytes and that pyrrolidinedithiocarbamate (PDTC), an anti-oxidant reagent, completely suppressed IFN-gamma-induced hepatic apoptosis. | Reactive Oxygen Species | interferon gamma | Homo sapiens |
| 3 | In this study, we found that IFN-gamma induced generation of reactive oxygen species (ROS) in primary hepatocytes and that pyrrolidinedithiocarbamate (PDTC), an anti-oxidant reagent, completely suppressed IFN-gamma-induced hepatic apoptosis. | Reactive Oxygen Species | interferon gamma | Homo sapiens |
| 4 | However, IFN-gamma also induced the generation of ROS in IRF-1-deficient hepatocytes, cells insensitive to IFN-gamma-induced apoptosis. | Reactive Oxygen Species | interferon gamma | Homo sapiens |
| 5 | Both the ROS and ER stress induced by IFN-gamma may be complementary mediators that induce apoptosis in primary hepatocytes. | Reactive Oxygen Species | interferon gamma | Homo sapiens |